Colorectal adenocarcinomas downregulate the mitochondrial Na+/Ca2+ exchanger NCLX to drive metastatic spread
T. Pathak, M. Gueguinou, V. Walter, C. Delierneux, M. T. Johnson, X. Zhang, P. Xin, R. E. Yoast, S. M. Emrich, G. S. Yochum, I. Sekler, W. A. Koltun, D. L. Gill, N. Hempel, M. Trebak
This study shows that reduced NCLX expression in colorectal tumors leads to mtCa2+ overload, promoting metastasis and chemoresistance through mtROS/HIF1 signaling.
bioRxiv · May 7, 2020 · PreprintCancer Biology