A targeted cell lysis mechanism facilitates toxin release in Clostridioides difficile
Shannon Lynn Kordus, Kateryna Nabukhotna, Rubén Cano Rodríguez, Evan Krystofiak, Kevin O. Childress, Anna J. Smith, Oleg Kovtun, Natalie Loveridge, W. C. Ball, Grace Moore, Mary Kay Washington, Nicholas O. Markham, Dana Borden Lacy
The paper identifies a targeted cell lysis mechanism driven by TcdE that facilitates toxin release in Clostridioides difficile, revealing it as a bet-hedging strategy.
bioRxiv · Sep 22, 2025 · PreprintMicrobiology