Author

W. D. Lee

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Research Focus:metabolism & bioenergetics· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:metabolomics· 1 Approach:statistical model· 1

Frequent Co-Authors

J. D. Rabinowitz· 2 shared A. Roichman· 1 shared B. P. Leitner· 1 shared C. R. Bartman· 1 shared C. S. R. Jankowski· 1 shared C. Song· 1 shared F. Long· 1 shared F. Song· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersPhysiology

J. D. Rabinowitz

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Osteoblast-intrinsic defect in glucose metabolism impairs bone formation in type II diabetic mice

F. Song, W. D. Lee, T. Marmo, X. Ji, C. Song, X. Liao, R. Seeley, L. Yao, H. Liu, F. Long

This study shows that impaired glucose metabolism in osteoblasts causes reduced bone formation in type 2 diabetic mice, and identifies potential therapeutic targets.

bioRxiv · Jan 16, 2023Physiology

Tissue-Specific and Interorgan Metabolic Reprogramming Maintains Tolerance to Sepsis

B. P. Leitner, W. D. Lee, W. Zhu, X. Zhang, R. C. Gaspar, Z. Li, J. D. Rabinowitz, R. J. Perry

This study identifies tissue-specific metabolic reprogramming in sepsis, showing that mitochondrial adaptations in vital organs, not global dysfunction, underlie sepsis tolerance.

bioRxiv · Oct 8, 2022 · PreprintPhysiology

Slow TCA flux implies low ATP production in tumors

C. R. Bartman, Y. Shen, W. D. Lee, T. TeSlaa, C. S. R. Jankowski, L. Wang, L. Yang, A. Roichman, V. Bhatt, T. Lan, Z. S. Hu, X. Xing, W. Lu, J. Y. Guo, J. D. Rabinowitz

This study quantifies TCA flux in tumors and healthy tissues, finding suppressed ATP production in tumors despite increased glycolysis.

bioRxiv · Oct 4, 2021 · PreprintCancer Biology