Author

R. Seeley

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 4 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 5 Approach:experimental assay· 4 Assay:bulk RNA-seq· 3 Research Focus:metabolism & bioenergetics· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:host-pathogen & immune response· 2

Frequent Co-Authors

D. A. Sandoval· 2 shared J. H. Shin· 2 shared N. Bozadjieva Kramer· 2 shared A. A. Fodor· 1 shared A. G. Lewis· 1 shared A. J. Pfeil· 1 shared A. Marti· 1 shared C. F. Burant· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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2 shared papersPhysiology

D. A. Sandoval

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Author profile →

5 papers

Recent·Most cited

Calorie Restriction Outperforms Bariatric Surgery in a Murine Model of Obesity and Triple-Negative Breast Cancer

M. F. Coleman, K. K. Camp, T. L. McFarlane, S. S. Doerstling, S. A. Khatib, E. T. Rezeli, A. G. Lewis, A. J. Pfeil, L. A. Smith, F. Fouladi, W. Gong, E. M. Glenny, J. S. Parker, G. L. Milne, I. M. Carroll, , S. D. Hursting

This study compares the effects of bariatric surgery and calorie restriction on obesity-driven triple-negative breast cancer in mice, finding calorie restriction more effective in reversing tumor growth.

bioRxiv · May 19, 2023 · PreprintCancer Biology

Osteoblast-intrinsic defect in glucose metabolism impairs bone formation in type II diabetic mice

F. Song, W. D. Lee, T. Marmo, X. Ji, C. Song, X. Liao, R. Seeley, L. Yao, H. Liu, F. Long

This study shows that impaired glucose metabolism in osteoblasts causes reduced bone formation in type 2 diabetic mice, and identifies potential therapeutic targets.

bioRxiv · Jan 16, 2023Physiology

GDF15 Is Required for Cold-Induced Thermogenesis and Contributes to Improve Systemic Metabolic Health Following Loss of OPA1 in Brown Adipocytes

J. Jena, L. M. G. Pena, E. T. Weatherford, A. Marti, S. H. Bjorkman, K. Kato, J. Koneru, J. H. Chen, R. Seeley, E. D. Abel, R. O. Pereira

This study identifies GDF15 as a mediator of improved metabolic health and thermogenesis in OPA1-deficient brown adipocytes, showing its role in glucose homeostasis and cold-induced thermogenesis.

bioRxiv · Dec 23, 2022Physiology

Intestinal-derived FGF15 preserves muscle and bone mass following sleeve gastrectomy

N. Bozadjieva Kramer, J. H. Shin, Y. Shao, R. Gutierrez-Aguilar, Z. Li, K. M. Heppner, S. Chiang, S. G. Vargo, K. Granger, D. A. Sandoval, O. MacDougald, R. Seeley

This study shows that intestinal FGF15 protects against muscle and bone loss after sleeve gastrectomy in mice.

bioRxiv · Jun 2, 2020 · PreprintPhysiology

The role of elevated branched chain amino acids in the potent effects of vertical sleeve gastrectomy to reduce weight and improve glucose regulation in mice

N. Bozadjieva Kramer, S. S. Evers, J. H. Shin, S. Silverwood, Y. Wang, C. F. Burant, D. A. Sandoval, R. Seeley

This study investigates whether reduced branched-chain amino acid (BCAA) levels after vertical sleeve gastrectomy (VSG) contribute to metabolic improvements in mice, finding that BCAA reduction is not necessary for weight loss or glucose tolerance.

bioRxiv · Jun 1, 2020Physiology