Author

J. Y. Guo

Primary ORCID profile (0000-0002-6402-2124 · 1 paper)Unclaimed ORCID profile · follow to get notified of new preprints

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Same name, identified by ORCID

J. Y. GuoiD1 paper · Northwest A&F University

Biology Disciplines

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Cancer Biology· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:host-pathogen & immune response· 2 Research Focus:metabolism & bioenergetics· 2 Assay:metabolomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

V. Bhatt· 3 shared Z. S. Hu· 3 shared J. D. Rabinowitz· 2 shared T. Lan· 2 shared X. Luo· 2 shared A. Roichman· 1 shared C. Li· 1 shared C. M. Mu· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersCancer Biology

V. Bhatt

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

G6PD Maintains Redox Homeostasis and Biosynthesis in LKB1-Deficient KRAS-Driven Lung Cancer

T. Lan, S. Arastu, S. Wang, J. Lam, W. Wang, V. Bhatt, E. C. Lopes, Z. S. Hu, M. Sun, X. Luo, J. M. Ghergurovich, C. Li, X. Su, J. D. Rabinowitz, E. White, J. Y. Guo

This study shows that G6PD is critical for redox balance and biosynthesis in LKB1-deficient KRAS-driven lung cancer, but not in KP tumors, and identifies potential therapeutic strategies.

bioRxiv · Oct 6, 2023 · PreprintCancer Biology

Mechanism of ozone alleviation of malignant ascites in hepatocellular carcinoma through inhibition of NETs

F. Han, C. M. Mu, K. Bian, Z. Mu, Q. Duan, J. Y. Guo, J. Ma, L. Jin, W. Liu, F. Chen

This study shows ozone reduces malignant ascites in hepatocellular carcinoma by inhibiting NETs through AMPK activation and SR-A mediated phagocytosis of DAMPs.

bioRxiv · Apr 26, 2023Cancer Biology

Slow TCA flux implies low ATP production in tumors

C. R. Bartman, Y. Shen, W. D. Lee, T. TeSlaa, C. S. R. Jankowski, L. Wang, L. Yang, A. Roichman, V. Bhatt, T. Lan, Z. S. Hu, X. Xing, W. Lu, J. Y. Guo, J. D. Rabinowitz

This study quantifies TCA flux in tumors and healthy tissues, finding suppressed ATP production in tumors despite increased glycolysis.

bioRxiv · Oct 4, 2021 · PreprintCancer Biology

Autophagy Compensates for Lkb1 Loss to Maintain Adult Mice Homeostasis and Survival

J. Y. Guo, K. Khayati, V. Bhatt, Z. S. Hu, S. Fahumy, X. Luo

This study shows autophagy compensates for Lkb1 loss in adult mice, improving survival and mitigating metabolic and intestinal defects.

bioRxiv · Aug 26, 2020Cell Biology