W. E. Swords

Comparative genomics of clinical Stenotrophomonas maltophilia isolates reveals regions of diversity which correlate with colonization and persistence in vivo

This study compares the genomes of clinical S. maltophilia isolates to identify genomic regions linked to colonization and persistence in vivo, particularly in coinfection with P. aeruginosa.

Pathogenesis of Achromobacter xylosoxidans respiratory infections: colonization and persistence of airway epithelia and differential gene expression in synthetic cystic fibrosis sputum medium

Pseudomonas aeruginosa promotes persistence of Stenotrophomonas maltophilia via increased adherence to depolarized respiratory epithelium

This study shows Pseudomonas aeruginosa enhances Stenotrophomonas maltophilia persistence in CF lungs by disrupting epithelial barriers and promoting adherence via type IV pilus mechanisms.

A phasevarion controls multiple virulence traits, including expression of vaccine candidates, in Streptococcus pneumoniae

This study shows that the SpnIII phasevarion in S. pneumoniae affects multiple virulence traits and vaccine candidate expression, highlighting its importance in vaccine design.

Poly (acetyl arginyl) glucosamine attenuates Pseudomonas aeruginosa in a rat lung infection model

This study evaluates PAAG's effect on P. aeruginosa biofilms and lung infections in rats, finding it reduces bacterial biomass and inflammation.

Nontypeable Haemophilus influenzae redox recycling of protein thiols promotes resistance to oxidative killing and bacterial survival in biofilms in a smoke related infection model

This study shows that thiol redox homeostasis in NTHi promotes biofilm persistence and oxidative resistance in a smoke-related infection model.

Nontypeable Haemophilus influenzae infection impedes Pseudomonas aeruginosa colonization and persistence in mouse respiratory tract

This study shows that NTHi infection reduces Pa colonization in mice, likely by enhancing host immunity rather than direct competition.

Mutations in bacterial genes induce unanticipated changes in the relationship between bacterial pathogens in experimental otitis media

The paper investigates how mutations in bacterial genes alter interactions between pathogens in experimental otitis media by analyzing co-infection kinetics in chinchillas.