G. Merlino

Stochastic modelling of single-cell gene expression adaptation reveals non-genomic contribution to evolution of tumor subclones

The paper models gene expression adaptation in tumor subclones using stochastic processes and finds non-genetic mechanisms drive subclonal evolution and treatment response.

Melanoma clonal subline analysis uncovers heterogeneity-driven immunotherapy resistance mechanisms

The paper analyzes melanoma clonal sublines to uncover how intratumoral heterogeneity drives resistance to immunotherapy.

Transitory Schwann Cell Precursor and hybrid states underpin melanoma therapy resistance and metastasis

This paper identifies transitory Schwann Cell Precursor and hybrid states in melanoma that correlate with therapy resistance and metastasis, and shows targeting Hdac2 can sensitize tumors to treatment.

A novel PD-L1-targeted shark VNAR single domain-based CAR-T strategy for treating breast cancer and liver cancer

This paper develops a PD-L1-targeted shark VNAR-based CAR-T strategy that effectively targets breast and liver cancer cells and reduces tumor metastasis in mice.

Germline modifiers of the tumor immune microenvironment implicate drivers of cancer risk and immunotherapy response

The paper identifies germline variants associated with the tumor immune microenvironment, linking them to cancer risk and immunotherapy response.

Multi-model preclinical platform predicts clinical response of melanoma to immunotherapy

The paper develops a preclinical platform using syngeneic mouse models to predict melanoma patient response to immunotherapy and identifies a melanocytic plasticity signature linked to treatment outcomes.

Melanoblast transcriptome analysis reveals novel pathways promoting melanoma metastasis

The paper analyzes the melanoblast transcriptome to identify genes involved in melanoma metastasis and discovers a 43-gene signature predictive of patient survival.