Knockout of liver fluke granulin, Ov-grn-1, impedes malignant transformation during chronic infection with Opisthorchis viverrini
S. Chaiyadet, S. Tangkawattana, M. J. Smout, W. Ittiprasert, V. H. Mann, R. Deenonpoe, P. Arunsan, A. Loukas, P. J. Brindley, T. Laha
This study shows that knocking out the liver fluke gene Ov-grn-1 reduces malignant transformation in a hamster model of opisthorchiasis-associated cholangiocarcinoma.
bioRxiv · Dec 10, 2021Cancer Biology