Author

P. J. Brindley

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Microbiology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Assay:bulk RNA-seq· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1

Frequent Co-Authors

A. Loukas· 3 shared G. Rinaldi· 2 shared M. J. Smout· 2 shared S. Chaiyadet· 2 shared T. Laha· 2 shared V. H. Mann· 2 shared W. Ittiprasert· 2 shared A. Pagan· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersCell Biology

A. Loukas

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Tetraspanins from Opisthorchis viverrini stimulate cholangiocyte migration and inflammatory cytokine production.

A. Ruangsuwast, M. J. Smout, P. J. Brindley, A. Loukas, T. Laha, S. Chaiyadet

This study shows that O. viverrini tetraspanins enhance cholangiocyte proliferation, cytokine production, and migration, contributing to a cancerous microenvironment.

bioRxiv · Jun 12, 2023 · PreprintCell Biology

Differential excretory/secretory proteome of the adult female and male stages of the human blood fluke, Schistosoma mansoni

E. T. Kenney, V. H. Mann, W. I. Tanno, B. A. Rosa, M. Mitreva, B. K. Bracken, A. Loukas, P. J. Brindley, J. Sotillo

The paper identifies and compares excretory/secretory proteins from adult male and female Schistosoma mansoni worms using proteomics, revealing sex-specific functional differences.

bioRxiv · May 22, 2022Microbiology

Knockout of liver fluke granulin, Ov-grn-1, impedes malignant transformation during chronic infection with Opisthorchis viverrini

S. Chaiyadet, S. Tangkawattana, M. J. Smout, W. Ittiprasert, V. H. Mann, R. Deenonpoe, P. Arunsan, A. Loukas, P. J. Brindley, T. Laha

This study shows that knocking out the liver fluke gene Ov-grn-1 reduces malignant transformation in a hamster model of opisthorchiasis-associated cholangiocarcinoma.

bioRxiv · Dec 10, 2021Cancer Biology

Tumor Necrosis Factor and Schistosoma mansoni egg antigen Omega-1 shape distinct aspects of the early egg-induced granulomatous response

L. Ramakrishnan, K. K. Takaki, F. J. Roca, G. Schramm, R. H. P. Wilbers, W. Ittiprasert, P. J. Brindley, G. Rinaldi, M. Berriman, A. Pagan

This study investigates how TNF and omega-1 from Schistosoma mansoni eggs influence granuloma formation in zebrafish, showing distinct roles in macrophage recruitment and granuloma enlargement.

bioRxiv · Sep 29, 2020Microbiology

Helminth infection-induced carcinogenesis: spectrometric insights from the liver flukes, Opisthorchis and Fasciola

M. J. Gouveia, M. Y. Pakharukova, B. Sripa, G. Rinaldi, P. J. Brindley, V. A. Mordvinov, F. Gärtner, J. M. C. d. Costa, N. Vale

The paper compares metabolite profiles of liver flukes to investigate carcinogenic potential, finding differences in oxysterol-like metabolites between carcinogenic and non-carcinogenic species.

bioRxiv · Apr 11, 2019Cancer Biology