W. Kühlbrandt

The paper determines the structure of an Mrp antiporter using cryo-EM and simulates its mechanism, revealing a histidine-switch critical for ion translocation.

This study identifies Ca2+-mediated higher-order assembly of b0,+AT-rBAT as critical for system b0,+ trafficking and reveals its role in type I cystinuria.

The paper determines the structure of the hexameric fungal plasma membrane proton pump Pma1 in its auto-inhibited state and explores its functional implications.

The paper presents a high-resolution cryo-EM structure of mitochondrial complex I from Yarrowia lipolytica, revealing proton translocation pathways and conformational changes linked to proton pumping.

This paper determines the cryo-EM structure of mitochondrial ATP synthase, revealing rotary substates and mechanisms of F1-Fo coupling through atomic-level analysis.

The paper investigates protein denaturation at the air-water interface using electron cryo-microscopy and shows that hydrophilized graphene prevents this denaturation.