B. J. Murphy

Structural evidence for two-stage binding of mitochondrial ferredoxin 2 to the core iron-sulfur cluster assembly complex

The paper presents cryo-EM structures of the FDX2-bound core ISC complex, revealing two-stage binding of FDX2 and its role in electron transfer during [2Fe-2S] cluster biosynthesis.

Localising elements in single-particle reconstructions by REEL-EM: Reconstructed Electron Energy-Loss - Elemental Mapping

This paper introduces REEL-EM, a method combining EELS and single-particle image processing to enable elemental mapping in cryo-preserved macromolecular complexes, demonstrating reliable localization of abundant elements.

Structural and mechanistic insights into Streptococcus pneumoniae NADPH oxidase

This study presents cryo-EM structures of Streptococcus pneumoniae NADPH oxidase and elucidates its structural basis for activity, substrate specificity, and catalytic regulation.

Long-read RNA Sequencing Improves the Annotation of the Equine Transcriptome

The paper improves the equine transcriptome annotation using long-read RNA sequencing, achieving 45% better completeness and enhanced identification of alternative splicing and noncoding genes.

Structure of the membrane-bound formate hydrogenlyase complex from Escherichia coli

This study determines the cryo-EM structures of the membrane-bound formate hydrogen lyase complex from E. coli, revealing key structural features and potential mechanisms for hydrogen production and regulation.

Structure of the hexameric fungal plasma membrane proton pump in its auto-inhibited state

The paper determines the structure of the hexameric fungal plasma membrane proton pump Pma1 in its auto-inhibited state and explores its functional implications.

Rotary substates of mitochondrial ATP synthase reveal the basis of flexible F1-Fo coupling

This paper determines the cryo-EM structure of mitochondrial ATP synthase, revealing rotary substates and mechanisms of F1-Fo coupling through atomic-level analysis.