Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
4 papers
Recent·Most cited
D. C. McKinney, B. J. McMillan, M. Ranaghan…·A. Ianari
The paper identifies a first-in-class inhibitor, BRD0639, that targets the PRMT5-PBM interaction, disrupting SAP binding and reducing substrate methylation in cancer cells.
H. Keshishian, E. R. McDonald, R. Melanson…·S. A. Carr
The paper introduces SigPath, a mass spectrometry assay that quantifies 284 phosphosites across 200 phosphoproteins, revealing new insights into phospho-signaling in cancer models and human tumors.
A. C. Palmer, D. Plana, H. Gao…·J. A. Williams
This study identifies biomarker-guided treatment strategies for ovarian cancer using patient-derived tumor xenografts, finding that nearly 90% of PDXs responded to at least one targeted therapy.
K. M. Mulvaney, C. Blomquist, N. Acharya…·W. R. Sellers
The paper identifies a conserved peptide sequence in PRMT5 substrate adaptors that mediates their interaction with PRMT5 and shows its necessity for methylation of substrates like spliceosome, histones, and ribosome complexes.