Author

W. W. Cheng

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 2 Research Focus:host-pathogen & immune response· 1 Research Focus:protein folding & dynamics· 1 Research Focus:protein structure prediction· 1 Assay:structural biology· 1

Frequent Co-Authors

G. Brannigan· 3 shared J. T. Petroff· 3 shared D. F. Covey· 2 shared K. Krishnan· 2 shared L. J. Chen· 2 shared N. M. Dietzen· 2 shared A. Evers· 1 shared A. L. Germann· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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3 shared papersBiophysics

G. Brannigan

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Author profile →

4 papers

Recent·Most cited

Structural mechanism of leaflet-specific phospholipid modulation of a pentameric ligand-gated ion channel

J. T. Petroff, N. M. Dietzen, E. Santiago-McRae, B. Deng, M. S. Washington, L. J. Chen, K. T. Moreland, Z. Deng, M. Rau, J. A. Fitzpatrick, P. Yuan, T. T. Joseph, J. Henin, G. Brannigan, W. W. Cheng

The paper shows phosphatidylglycerol stabilizes the open state of ELIC by binding to a specific outer leaflet site, identified through structural and functional analyses.

bioRxiv · Jun 7, 2022 · PreprintBiophysics

Polyunsaturated fatty acids inhibit a pentameric ligand-gated ion channel through one of two binding sites

N. M. Dietzen, M. J. Arcario, L. J. Chen, J. T. Petroff, K. Krishnan, G. Brannigan, D. F. Covey, W. W. Cheng

This study identifies two fatty acid binding sites in ELIC and shows that DHA selectively inhibits the channel by binding to a specific site in the agonist-bound state.

bioRxiv · Oct 8, 2021Biochemistry

Site-specific effects of neurosteroids on GABAA receptor activation and desensitization

Y. Sugasawa, W. W. Cheng, J. Bracamontes, Z.-W. Chen, L. Wang, A. L. Germann, S. R. Pierce, T. C. Senneff, K. Krishnan, D. E. Reichert, D. F. Covey, G. Akk, A. Evers

This study identifies how neurosteroids interact with three distinct sites on the GABAA receptor, influencing activation and desensitization, and shows that site-specific binding determines their functional effects.

bioRxiv · Apr 27, 2020Biophysics

Direct Binding of Phosphatidylglycerol at Specific Sites Modulates Desensitization of a Pentameric Ligand-Gated Ion Channel

A. Tong, J. T. Petroff, F.-F. Hsu, P. A. Schmidpeter, C. M. Nimigean, L. Sharp, G. Brannigan, W. W. Cheng

The paper shows that phosphatidylglycerol binds to and stabilizes the pentameric ligand-gated ion channel ELIC, reducing desensitization.

bioRxiv · Aug 7, 2019Biophysics