Author

J. A. Fitzpatrick

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Approach:biophysical modeling· 1 Research Focus:host-pathogen & immune response· 1 Assay:organoid / primary culture· 1 Research Focus:protein folding & dynamics· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

A. L. Bailey· 1 shared A. L. Bredemeyer· 1 shared A. P. Nair· 1 shared A. S. Rali· 1 shared B. Deng· 1 shared C. Schmidt· 1 shared C.-Y. Lin· 1 shared D. Hobohm· 1 shared

Activity by Year

2018-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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1 shared paperImmunology

A. L. Bailey

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Structural mechanism of leaflet-specific phospholipid modulation of a pentameric ligand-gated ion channel

J. T. Petroff, N. M. Dietzen, E. Santiago-McRae, B. Deng, M. S. Washington, L. J. Chen, K. T. Moreland, Z. Deng, M. Rau, J. A. Fitzpatrick, P. Yuan, T. T. Joseph, J. Henin, G. Brannigan, W. W. Cheng

The paper shows phosphatidylglycerol stabilizes the open state of ELIC by binding to a specific outer leaflet site, identified through structural and functional analyses.

bioRxiv · Jun 7, 2022 · PreprintBiophysics

SARS-CoV-2 Infects Human Engineered Heart Tissues and Models COVID-19 Myocarditis

A. L. Bailey, O. Dmytrenko, L. Greenberg, A. L. Bredemeyer, P. Ma, J. Liu, V. Penna, L. Lai, E. S. Winkler, S. Sviben, E. Brooks, A. P. Nair, K. A. Heck, A. S. Rali, L. Simpson, , K. J. Lavine

This study shows SARS-CoV-2 infects human engineered heart tissues, causing myocarditis-like features, and identifies ACE2 and proteases as entry factors.

bioRxiv · Nov 4, 2020Immunology

PolyA tracks and poly-lysine repeats are the Achilles heel of Plasmodium falciparum

S. Pavlovic Djuranovic, J. Erath, R. J. Andrews, P. O. Bayguinov, J. J. Chung, D. L. Chalker, J. A. Fitzpatrick, W. N. Moss, P. Szczesny, S. Djuranovic

This study shows that Plasmodium falciparum efficiently translates polyA tracks and poly-lysine repeats without triggering mRNA surveillance pathways, giving it an advantage in infectivity.

bioRxiv · Sep 18, 2018Microbiology