Spatiotemporal manipulation of ciliary glutamylation reveals its roles in intraciliary trafficking and Hedgehog signaling
S.-R. Hong, C.-L. Wang, Y.-S. Huang, Y.-C. Chang, Y.-C. Chang, G. V. Pusapati, C.-Y. Lin, N. Hsu, H.-C. Cheng, Y.-C. Chiang, W.-E. Huang, N. C. Shaner, R. Rohatgi, T. Inoue, Y.-C. Lin
The paper develops a method to rapidly deplete tubulin glutamylation in primary cilia, revealing its role in intraflagellar transport and Hedgehog signaling without affecting other PTMs.
bioRxiv · Mar 15, 2018Cell Biology