Author

W.-W. Lim

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Immunology· 1 Pathology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 4 Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Research Focus:cell signaling & trafficking· 2 Assay:scRNA-seq· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Approach:deep learning· 1

Frequent Co-Authors

B. Ng· 3 shared S. A. Cook· 2 shared S. Cook· 2 shared S. Schafer· 2 shared S. Viswanathan· 2 shared A. A. Hii· 1 shared A. A. Widjaja· 1 shared A. Brandt· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersImmunology

B. Ng

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Identification of a targetable ST2-expressing fibroblast subset driving Peutz-Jeghers syndrome polyposis

E. Domenech-Moreno, W.-W. Lim, A. Brandt, T. Lemmetyinen, E. Viitala, T. P. Makela, S. Cook, S. Ollila

This study identifies ST2-expressing fibroblasts as drivers of Peutz-Jeghers syndrome polyposis and shows IL-11 as a therapeutic target.

bioRxiv · Nov 29, 2023 · PreprintCancer Biology

Interleukin-11 causes alveolar type 2 cell dysfunction and prevents alveolar regeneration

B. Ng, K. Y. Huang, C. J. Pua, W.-W. Lim, F. Kuthubudeen, A. A. Hii, S. Viswanathan, E. G. Petretto, S. A. Cook

This study shows IL11 impairs AT2 cell differentiation into AT1 cells and blocks lung regeneration in mice and humans.

bioRxiv · Nov 11, 2022Immunology

Redefining Interleukin 11 as a regeneration-limiting hepatotoxin

A. A. Widjaja, J. R. Dong, E. Adami, S. Viswanathan, B. NG, B. K. Singh, W.-W. Lim, J. Zhou, L. S. Pakkiri, S. G. Shekeran, J. Tan, S. Y. Lim, M. Wang, R. Holgate, A. Hearn, , S. A. Cook

This study reveals IL11 as a hepatotoxin that limits liver regeneration after APAP overdose, showing its inhibition of endogenous IL11 activity protects mice.

bioRxiv · Nov 4, 2019Physiology

Interleukin 11 expression causes murine inflammatory bowel disease

W.-W. Lim, B. Ng, A. Widjaja, C. Xie, L. Su, N. Ko, S.-Y. Lim, X.-Y. Kwek, S. Lim, S. Cook, S. Schafer

This study shows that IL11 secretion from stromal cells drives inflammatory bowel disease in mice, suggesting IL11 as a therapeutic target for inflammatory bowel disease.

bioRxiv · Sep 5, 2019Pathology