Author

W.-Y. Chen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Bioengineering· 1 Cell Biology· 1 Immunology· 1 Microbiology· 1 Zoology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Assay:proteomics· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

H.-C. Wu· 3 shared H.-T. Lin· 3 shared K.-H. Liang· 2 shared M. Kumari· 2 shared Y.-C. Chou· 2 shared B. C.-M. Tan· 1 shared C.-C. Lee· 1 shared C.-C. Lin· 1 shared

Activity by Year

2021-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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3 shared papersImmunology

H.-C. Wu

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Testing the efficacy of different molecular tools for parasite conservation genetics: a case study using horsehair worms (Phylum Nematomorpha)

M. De Vivo, W.-Y. Chen, J.-P. Huang

The paper evaluates ddRADseq and COXI sequencing for estimating genetic diversity in horsehair worms, finding that larger sample sizes and more loci improve Ne estimation and reveal Pleistocene demographic changes.

bioRxiv · Feb 21, 2023Zoology

Sensitive and specific miRNA in situ hybridization using partially methylated phosphotriester antisense DNA probes

P.-H. Wang, C.-W. Chang, T. Z. Jia, B. C.-M. Tan, Y.-H. Chi, W.-Y. Chen

This study demonstrates that partially methylated nDNA probes enhance miRNA detection specificity and sensitivity in in situ hybridization compared to conventional DNA probes.

bioRxiv · Jun 12, 2022 · PreprintBioengineering

Broadly neutralizing antibodies against Omicron variants of SARS-CoV-2 derived from mRNA-lipid nanoparticle-immunized mice

R.-M. Lu, K.-H. Liang, H.-L. Chiang, F.-F. Hsu, H.-T. Lin, W.-Y. Chen, F.-Y. Ke, M. Kumari, Y.-C. Chou, H.-C. Wu

This paper develops broadly neutralizing antibodies against Omicron variants of SARS-CoV-2 using mRNA-lipid nanoparticle immunization in mice, showing effectiveness against multiple variants.

bioRxiv · Apr 19, 2022Immunology

Mettl3-mediated m6A modification of Fgf16 restricts cardiomyocyte proliferation during heart regeneration

F.-Q. Jiang, J.-X. Chen, W.-Y. Chen, W.-L. Zhao, G.-H. Song, C.-Q. Liang, Y.-M. Zhou, H.-L. Huang, R.-J. Huang, H. Zhao, K.-S. Park, Z. Ju, D. Cai, X.-F. Qi

This study shows that Mettl3-mediated m6A modification of Fgf16 limits cardiomyocyte proliferation and heart regeneration in mice.

bioRxiv · Feb 27, 2022Cell Biology

Omicron-specific mRNA vaccine induced potent neutralizing antibody against Omicron but not other SARS-CoV-2 variants

I.-J. Lee, C.-P. Sun, P.-Y. Wu, Y.-H. Lan, I.-H. Wang, W.-C. Liu, S.-C. Tseng, S.-I. Tsung, Y.-C. Chou, M. Kumari, Y.-W. Chang, H.-F. Chen, Y.-S. Lin, T. -Y. Chen, C.-W. Chiu, , M.-H. Tao

This study evaluates Omicron-specific mRNA vaccines and finds they induce strong neutralizing antibodies against Omicron but not other variants, while bivalent vaccines show broader neutralizing activity.

bioRxiv · Jan 31, 2022Microbiology

Impacts on the structure-function relationship of SARS-CoV-2 spike by B.1.1.7 mutations

T.-J. Yang, P.-Y. Yu, Y.-C. Chang, K.-H. Liang, H.-C. Tso, M.-R. Ho, W.-Y. Chen, H.-T. Lin, H.-C. Wu, S.-T. D. Hsu

This study examines how B.1.1.7 mutations affect the structure and function of SARS-CoV-2 spike protein, showing changes in receptor binding and antibody neutralization.

bioRxiv · May 11, 2021 · PreprintBiochemistry