Spatiotemporal profiling reveals the impact of caloric restriction on mammalian brain aging
Zehao Zhang, Alexander E. Epstein, Chloe Schaefer, Abdulraouf Abdulraouf, Weirong Jiang, Wei You Zhou, Junyue Cao
This study uses single-nucleus genomics and spatial transcriptomics to show that caloric restriction modulates aging-related changes in mouse brains, reducing inflammation and stress pathways while restoring circadian and cognitive genes.
Cell Reports · Aug 19, 2025Peer-reviewedGenomics