Abdulraouf Abdulraouf

This study constructs a pan-cancer single-cell multi-omic atlas to uncover gene regulatory principles in cancer cell states and environmental features across diverse cancer types.

This study constructs a single-cell chromatin accessibility atlas across mouse tissues to reveal age-related cellular and epigenomic changes, showing widespread population shifts and sex-dependent dynamics.

This study uses single-nucleus genomics and spatial transcriptomics to show that caloric restriction modulates aging-related changes in mouse brains, reducing inflammation and stress pathways while restoring circadian and cognitive genes.

EnrichSci enables targeted profiling of specific cell types in complex tissues, revealing aging-associated molecular dynamics and post-transcriptional regulation.

The paper introduces PerturbFate, a single-cell CRISPR screening platform, and finds convergent cell state dynamics across diverse genetic perturbations in melanoma cells.

PanSci, a single-cell transcriptome atlas of over 20 million cells throughout the mouse lifespan, unveils the temporal architecture of aging-associated cellular population dynamics, organ-specific immune cell shifts, and the lymphocytes role in organismal aging.

IRISeq, an optics-free spatial transcriptomics method, uncovers aging-related changes in spatial gene expression and focal cell interactions in brain aging.

The paper develops a high-throughput single-cell genomics approach to study age-related and Alzheimer's disease-associated cell population dynamics and molecular signatures in human and mouse brains.

The paper identifies a transient hyperactive neuronal state in early Alzheimer's disease using single-nucleus transcriptomics from living patients.

The paper shows enzymatic dissociation causes gene expression changes in microglia and proposes a protocol to reduce these artifacts in scRNA-seq.

The paper identifies ten distinct midbrain dopaminergic neuron populations in Parkinson's disease, highlighting an AGTR1-expressing subtype vulnerable to degeneration and associated with PD risk genes.