Author

Alexander E. Epstein

Rockefeller UniversityORCID 0000-0002-7784-9040Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Research Focus:gene regulatory network inference· 3 Assay:scRNA-seq· 3 Approach:experimental assay· 2 Organism:human· 2 Organism:mouse· 2 Assay:spatial transcriptomics· 2

Frequent Co-Authors

Abdulraouf AbdulraoufiD· 2 shared Chloe SchaeferiD· 2 shared Junyue CaoiD· 2 shared Wei You ZhouiD· 2 shared Zehao ZhangiD· 2 shared Adam BendalliD· 1 shared Adam Pickles· 1 shared Andras Sziraki· 1 shared

Activity by Year

2023-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersGenomics

Abdulraouf AbdulraoufORCID

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3 papers

Recent·Most cited

Spatiotemporal profiling reveals the impact of caloric restriction on mammalian brain aging

Zehao Zhang, Alexander E. Epstein, Chloe Schaefer, Abdulraouf Abdulraouf, Weirong Jiang, Wei You Zhou, Junyue Cao

This study uses single-nucleus genomics and spatial transcriptomics to show that caloric restriction modulates aging-related changes in mouse brains, reducing inflammation and stress pathways while restoring circadian and cognitive genes.

Cell Reports · Aug 19, 2025Peer-reviewedGenomics

A single factor for safer cellular rejuvenation

Lucas Paulo de Lima Camillo, Rihab Gam, Katsiaryna Maskalenka, Francis Leblanc, Gustavo Antonio Urrutia, Gabriel Mejia, Henry E. Miller, Christopher P. Wardlaw, Adam Pickles, Laura Everton, Ringaile Zaksauskaite, Rejina B. Khan, Andreas Welsh, Samira Gambo, Stephany Gallardo, , Brendan Swain

This paper identifies SB000, a single gene factor that rejuvenates cells from multiple germ layers without inducing pluripotency, rivaling the effectiveness of Yamanaka factors.

bioRxiv · Jun 5, 2025 · PreprintCell Biology

A global view of aging and Alzheimer's pathogenesis-associated cell population dynamics and molecular signatures in the human and mouse brains

Andras Sziraki, Ziyu Lu, Jasper Lee, Gábor Bányai, Sonya Anderson, Abdulraouf Abdulraouf, Eli Metzner, Andrew Shuh-Huei Liao, Jason R. Banfelder, Alexander E. Epstein, Chloe Schaefer, Zihan Xu, Zehao Zhang, Li Gan, Peter T. Nelson, , Junyue Cao

The paper develops a high-throughput single-cell genomics approach to study age-related and Alzheimer's disease-associated cell population dynamics and molecular signatures in human and mouse brains.

Nature Genetics · Nov 30, 2023Peer-reviewedGenomics