Wei You Zhou

Single-cell multimodal profiling of pan-cancer cell lines uncovers gene regulatory principles underlying intrinsic cell states and environmental features

This study constructs a pan-cancer single-cell multi-omic atlas to uncover gene regulatory principles in cancer cell states and environmental features across diverse cancer types.

An organismal view of newborn cell dynamics in mammalian aging

The paper uses TrackerSci to analyze newborn cell dynamics across 21 mouse tissues at different ages, showing how aging affects cell renewal and composition.

Organism-wide cellular dynamics and epigenomic remodeling in mammalian aging

This study constructs a single-cell chromatin accessibility atlas across mouse tissues to reveal age-related cellular and epigenomic changes, showing widespread population shifts and sex-dependent dynamics.

Spatiotemporal profiling reveals the impact of caloric restriction on mammalian brain aging

This study uses single-nucleus genomics and spatial transcriptomics to show that caloric restriction modulates aging-related changes in mouse brains, reducing inflammation and stress pathways while restoring circadian and cognitive genes.

Uncovering Convergent Cell State Dynamics Across Divergent Genetic Perturbations Through Single-Cell High-Content CRISPR Screening

The paper introduces PerturbFate, a single-cell CRISPR screening platform, and finds convergent cell state dynamics across diverse genetic perturbations in melanoma cells.

A Panoramic View of Cell Population Dynamics in Mammalian Aging

PanSci, a single-cell transcriptome atlas of over 20 million cells throughout the mouse lifespan, unveils the temporal architecture of aging-associated cellular population dynamics, organ-specific immune cell shifts, and the lymphocytes role in organismal aging.

A global view of aging and Alzheimer's pathogenesis-associated cell population dynamics and molecular signatures in the human and mouse brains

The paper develops a high-throughput single-cell genomics approach to study age-related and Alzheimer's disease-associated cell population dynamics and molecular signatures in human and mouse brains.

PerturbSci-Kinetics: Dissecting key regulators of transcriptome kinetics through scalable single-cell RNA profiling of pooled CRISPR screens

PerturbSci-Kinetics enables analysis of transcriptome kinetics through single-cell RNA profiling of CRISPR screens, revealing key regulators in miRNA and mitochondrial RNA processing.

A comprehensive view of cell-type-specific temporal dynamics in human and mouse brains

This paper introduces TrackerSci, a technique to profile progenitor cells in mouse and human brains, revealing cell-type-specific dynamics and aging-related changes.

Transcriptional re-wiring by mutation of the yeast Hsf1 oligomerization domain

The paper identifies mutations in the yeast Hsf1 oligomerization domain that alter transcriptional programs and fitness under heat stress.

Characterizing the temporal dynamics of gene expression in single cells with sci-fate

The paper introduces sci-fate, a method to profile both newly synthesized and total transcriptomes in single cells, and applies it to study cortisol response dynamics in over 6,000 cells.

Minor QTLs mining through the combination of GWAS and machine learning feature selection

The paper combines GWAS with machine learning feature selection to identify minor QTLs associated with soybean branching, finding 1,770 SNPs and 328 related genes.

Minor QTLs mining through the combination of GWAS and machine learning feature selection

The paper combines GWAS with machine learning feature selection to identify minor QTLs associated with soybean branching, finding 1,770 SNPs and 328 related genes.