Brittney D Wick

The paper identifies YBX1 as a key transcription factor in shaping human prefrontal cortex molecular identity through CRISPR activation screens and organoid experiments.

The paper integrates single-cell and spatial multiomic data to show widespread reactivation of developmental programs in diseased human hearts, with insights into transcriptional factors and localized fetal reactivation.

The paper maps clonal hierarchies in glioblastoma using lineage-resolved single-cell data, revealing multiple non-redundant progenitors and identifying cell type-specific therapeutic targets.

The paper presents a single-nucleus RNA sequencing atlas of Aedes aegypti mosquitoes, identifying novel cell types and sexual dimorphism in gene expression across tissues.

This study uses single-cell analysis of dup15q syndrome to identify developmental and postnatal molecular changes in autism, revealing cell-type specific dysregulation and shared vulnerabilities with idiopathic ASD.

The paper integrates seven single-cell transcriptomic datasets to generate 225 meta-modules, identifying key gene networks involved in human cortical cell subtype specification and validating their roles in neurodevelopment.

PanSci, a single-cell transcriptome atlas of over 20 million cells throughout the mouse lifespan, unveils the temporal architecture of aging-associated cellular population dynamics, organ-specific immune cell shifts, and the lymphocytes role in organismal aging.

This study identifies a neurovascular progenitor cell type in glioblastoma that links distinct malignant lineages and influences tumor composition and survival.

The paper constructs a single-cell transcriptomic atlas of human cortical development, identifying lineage and sex-specific gene expression programs linked to autism risk.

The paper investigates epigenomic and 3D chromatin conformation changes in human frontal cortex and hippocampus development using sn-m3C-seq, finding distinct chromatin conformations in neurons and glial cells and linking risk variants to regulatory regions.