X. Yao

This study shows that gamma secretase inhibitors reduce ovarian cancer growth and boost olaparib's effectiveness by targeting the Notch/jagged1 and Wnt/beta-catenin pathways.

This paper investigates the ligand recognition mechanism of PHF20L1 Tudor1, revealing a pre-existing open conformation that enables binding to both methylated proteins and small molecules.

This study evaluates the cytotoxicity of chloroquine and hydroxychloroquine in multiple cell lines and tissues using a dynamic imaging system and PBPK model, finding HCQ less toxic than CQ in most cases.

This paper develops and validates an LC/MS/MS method to quantify ceramides and dihydroceramides in human serum, revealing unique gestational patterns during pregnancy.

This study identifies DNA methylation of DZIP3 as a marker for early stage colorectal cancer, linked to aging and immune cell composition.

This study develops dihydroartemisinin-loaded magnetic nanoparticles to enhance chemodynamic therapy, showing improved ROS production and efficacy against breast cancer cells, including drug-resistant ones.

This study identifies Cqs2 as the critical determinant for orchestrating the unisexual cycle in Cryptococcus neoformans without requiring the sex-determination program.

This meta-analysis evaluates the prognostic value of Red Blood Cell Distribution Width (RDW) in Acute Kidney Injury (AKI) patients, finding a significant association but noting limitations due to small sample sizes.

The paper develops a machine learning framework to predict thermostable mutations for GPCRs, achieving higher success rates than systematic alanine scanning.

This study examines tannin and saponin degradation during co-composting of Camellia oleifera shell and seed cake, finding that higher seed cake proportions increase degradation rates but reduce C/N ratio and tannin content.

This study uses whole-genome sequencing of cancer samples to reconstruct the evolutionary history of 39 cancer types, identifying early and late-stage mutational patterns and driver genes.