Author

X.-H. Xing

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 3 Microbiology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:E. coli· 4 Research Focus:drug response / drug discovery· 3 Research Focus:gene regulatory network inference· 3 Assay:CRISPR screen· 2 Organism:bacteria (other)· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1

Frequent Co-Authors

C. Zhang· 5 shared B. Liu· 2 shared C. Guan· 2 shared J. Guo· 2 shared T. Wang· 2 shared Z. Xie· 2 shared B. Xu· 1 shared C. Luo· 1 shared

Activity by Year

2017-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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5 shared papersMicrobiology

C. Zhang

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Pooled CRISPR interference screening identifies crucial transcription factors in gas-fermenting Clostridium ljungdahlii

H. Zhang, H. Feng, X.-H. Xing, C. Zhang, Y. Gu

This study uses CRISPRi screening to identify transcription factors crucial for growth and carbon utilization in Clostridium ljungdahlii, improving ethanol production through deoR optimization.

bioRxiv · Feb 20, 2024 · PreprintMicrobiology

"Two-Birds-One-Stone" Oral Nanotherapeutic Designed to Target Intestinal Integrins and Regulate Redox Homeostasis for Ulcerative Colitis Treatment

L. Huang, W. Hu, L. Q. Huang, Q. X. Zhou, Z. Y. Song, H. Y. Tao, B. Xu, C. Y. Zhang, Y. Wang, X.-H. Xing

This paper develops an oral nanotherapeutic, OPNs@LMWH, that targets intestinal integrins and regulates redox homeostasis to treat ulcerative colitis, showing improved therapeutic efficacy and immune uptake.

bioRxiv · Jan 2, 2024 · PreprintBioengineering

Base Editor-Mediated Pooled Screening of Functional Mutations in Bacteria for Industrial Phenotypes

Y. Yuan, X. Liao, S. Li, X.-h. Xing, C. Zhang

The paper develops a base editor-mediated pipeline in E. coli to screen for functional single nucleotide variants under industrial stress conditions, identifying known and novel mutations.

bioRxiv · Sep 27, 2022Bioengineering

Microbial microdroplet culture system (MMC): an integrated platform for automated, high-throughput microbial cultivation and adaptive evolution

X. Jian, X. Guo, J. Wang, Z. L. Tan, X.-h. Xing, L. Wang, C. Zhang

The paper introduces a microbial microdroplet culture system (MMC) that enables automated, high-throughput microbial cultivation and adaptive evolution, showing improved growth rates compared to conventional methods.

bioRxiv · Dec 19, 2019Bioengineering

Improved sgRNA design in bacteria via genome-wide activity profiling

J. Guo, T. Wang, C. Guan, B. Liu, C. Luo, Z. Xie, C. Zhang, X.-H. Xing

The paper profiles sgRNA activity in E. coli to improve CRISPR/Cas9 efficiency and identifies limitations of existing prediction models.

bioRxiv · Feb 26, 2018Microbiology

Pooled CRISPR interference screens enable high-throughput functional genomics study and elucidate new rules for guide RNA library design in Escherichia coli

T. Wang, J. Guo, C. Guan, Y. Wu, B. Liu, Z. Xie, C. Zhang, X.-H. Xing

This paper develops a CRISPRi library for high-throughput functional genomics in E. coli, identifies sgRNA design rules, and validates gene-phenotype associations with high specificity.

bioRxiv · Apr 22, 2017Microbiology