C. Guan

Myosin II actively regulates Drosophila proprioceptors

Myosin II in Drosophila cap cells pre-stretches proprioceptive chordotonal neurons, modulating their mechanical response and sensory adaptation.

An insect's view of a numerosity illusion: a simple strategy may explain complex numerical performance in bumblebees

This study shows bumblebees can discriminate numerical ratios and are influenced by spatial arrangements, suggesting they may misperceive numerosity in an illusion similar to humans.

Modification of DNA by a viral enzyme and charged tRNA

The paper demonstrates how the phage Mu enzyme Mom uses charged tRNA to hypermodify adenine in DNA and reports the first in vitro reconstitution of this process.

Large-scale CRISPRi and transcriptomics of Staphylococcus epidermidis identify genetic factors implicated in commensal-pathogen lifestyle versatility

This study uses CRISPRi and transcriptomics to identify genetic factors in S. epidermidis that contribute to its commensal and pathogenic lifestyle versatility across diverse environments.

SNHG16 promotes cell proliferation and inhibits cell apoptosis via regulation of the miR-1303p/STARD9 axis in renal cell carcinoma

This study identifies SNHG16 as a promoter of renal cell carcinoma proliferation and inhibitor of apoptosis through the miR-1301-3p/STARD9 axis.

Inhibition mechanism of human sterol O-acyltransferase 1 by competitive inhibitor

This study determines the structure of human SOAT1 using cryo-EM and reveals how the inhibitor CI-976 blocks the active site.

A chemical counterpunch: Chromobacterium violaceum ATCC31532 produces violacein in response to translation-inhibiting antibiotics

This study shows that Chromobacterium violaceum produces violacein in response to translation-inhibiting antibiotics, revealing a novel interspecies interaction mechanism.

Rice annexin OsANN4 interacting with OsCDPK24, reduces root aerenchyma formation by modulating H2O2 under ABA treatment

The paper identifies OsANN4 as a rice annexin that interacts with OsCDPK24, modulates H2O2 levels, and affects root aerenchyma formation under ABA treatment.

Uniform distribution of 35S promoter-driven mDII auxin control sensor in leaf primordia

The paper confirms uniform distribution of the mDII control sensor in leaf primordia and validates asymmetric auxin signaling using DII/mDII and R2D2 sensors, while highlighting potential artifacts from light penetration in imaging.

Improved sgRNA design in bacteria via genome-wide activity profiling

The paper profiles sgRNA activity in E. coli to improve CRISPR/Cas9 efficiency and identifies limitations of existing prediction models.

Pooled CRISPR interference screens enable high-throughput functional genomics study and elucidate new rules for guide RNA library design in Escherichia coli

This paper develops a CRISPRi library for high-throughput functional genomics in E. coli, identifies sgRNA design rules, and validates gene-phenotype associations with high specificity.