In Vivo Multiplexed Modeling Reveals Diverse Roles of the TBX2 Subfamily and Egr1 in Ras-Driven Lung Adenocarcinoma
Athar Khalil, Trang Dinh, Meaghan Parks, Rebecca C. Obeng, Berkley E. Gryder, Adam M. Kresak, Yuxiang Wang, Jeff Maltas, Madeline Bedrock, Xiangzhen Wei, Zachary J. Faber, Mira Rahm, Jacob G. Scott, Thomas LaFramboise, Zhenghe Wang, Christopher D. McFarland
The paper develops a multiplexed mouse model to study TBX2 subfamily and Egr1 roles in Ras-driven lung cancer, finding Egr1 loss significantly increases tumor size and suggests immune dysregulation.
Genes & Diseases · Sep 3, 2025Peer-reviewedCancer Biology