Aging directs the differential evolution of KRAS-driven lung adenocarcinoma
Felicia Lazure, Stanislav Drápela, Xiaoxian Liu, John H. Lockhart, Hossein Kashfi, Nadir Sarigul, Didem Ilter, Elsa Renee Flores, Xuefeng Wang, Inna Smalley, Alex M. Jaeger, Xiaoqing Yu, Ana P. Gomes
This study uses single-cell RNA-sequencing to show that aging promotes KRAS-driven lung adenocarcinoma evolution toward a stem-like state through age-related changes in the tumor microenvironment.
bioRxiv · Jan 20, 2025 · PreprintCancer Biology