Epigenomic analysis of Parkinson’s disease neurons identifies Tet2 loss as neuroprotective
Lee L. Marshall, Bryan A. Killinger, Elizabeth Ensink, Peipei Li, Katie X. Li, Wei Cui, Noah Lubben, Matthew J. Weiland, Xinhe Wang, Juozas Gordevičius, Gerhard A. Coetzee, Jiyan Ma, Stefan V. Jovinge, Viviane Labrie
The paper identifies increased TET2 expression as a driver of epigenetic dysregulation in Parkinson’s disease neurons and shows that reducing Tet2 activity is neuroprotective in mice.
Nature Neuroscience · Aug 17, 2020Peer-reviewedNeuroscience