Biophysical modeling for accurate T cell specificity prediction of viral and tumor antigens
Zahra S. Ghoreyshi, Noah J. Tubo, Luca Arrigo Zammataro, Xizeng Mao, Ho Ngai, Duncheng Wang, Yibin Chen, Qiuming He, Eduardo Cisneros de la Rosa, Shoudan Liang, Priya Koppikar, Xingcheng Lin, Jeffrey J. Molldrem, Jason Thomas George
The paper develops a biophysical model to predict T cell receptor specificity for viral and tumor antigens using structural data and sequence-based clustering.
Nature Communications · Jun 23, 2026Peer-reviewedImmunology