Peptide molecular glues select between BET paralogues by exploiting allosteric sites and conformational dynamics
Karishma Patel, Biswaranjan Mohanty, Alexander R. Norman, Charlotte Franck, Petr Pachl, Lihua Yang, Xuefei Jing, Xavier J. Reid, James L. Walshe, Paul D. Solomon, Daniel H. Tran, Daniel Ford, Jason K. K. Low, Lorna E. Wilkinson‐White, Toby Passioura, , Joel P. Mackay
The paper identifies cyclic peptides that selectively inhibit BET BD paralogues by exploiting sequence differences and conformational dynamics, achieving high selectivity over existing inhibitors.
bioRxiv · Sep 24, 2025 · PreprintBiochemistry