Author

Lorna E. Wilkinson‐White

The University of SydneyORCID 0000-0002-2385-9358Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Approach:deep learning· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1 Assay:protein structure· 1

Frequent Co-Authors

Alexandra L. McAllaniD· 2 shared Arwaf S. AlharbiiD· 2 shared Ben CorryiD· 2 shared Daniel S. WenholziD· 2 shared Erandi Rupasinghe· 2 shared Julia I. EllyardiD· 2 shared Kim A. Lennox· 2 shared Liza CubedduiD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersImmunology

Alexandra L. McAllanORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Defining the Immunomodulatory Determinants of 3-mer Oligonucleotides on TLR7 and TLR8 sensing

Sunil Sapkota, Zhikuan Zhang, Christine Wolf, Akiko Fujimura, Daniel S. Wenholz, Mary Speir, Lorna E. Wilkinson‐White, ChakYin Chan, Pauline Percier, Abdallah Ladaycia, W. Samantha N. Jayasekara, Arwaf S. Alharbi, Alexandra L. McAllan, Erandi Rupasinghe, Nathan Beals, , Michael Paul Gantier

The paper identifies how 3-mer oligonucleotides with base and sugar modifications modulate TLR7 and TLR8 responses, leading to the development of a dual inhibitory oligonucleotide for autoimmune disease.

bioRxiv · Apr 29, 2026 · PreprintImmunology

2'-O-Methyl-guanosine 3-base RNA fragments mediate essential natural TLR7/8 antagonism

Arwaf S. Alharbi, Sunil Sapkota, Zhikuan Zhang, Ruitao Jin, Erandi Rupasinghe, W. Samantha N. Jayasekara, Dingyi Yu, Mary Speir, Lorna E. Wilkinson‐White, Liza Cubeddu, Julia I. Ellyard, Refaya Rezwan, Daniel S. Wenholz, Alexandra L. McAllan, Rui Gao, , Michael Paul Gantier

The paper identifies 2'-O-methyl-guanosine RNA fragments as natural antagonists of TLR7/8, preventing auto-immunity by inhibiting TLR signaling.

Nature Immunology · Feb 10, 2026Peer-reviewedImmunology

Peptide molecular glues select between BET paralogues by exploiting allosteric sites and conformational dynamics

Karishma Patel, Biswaranjan Mohanty, Alexander R. Norman, Charlotte Franck, Petr Pachl, Lihua Yang, Xuefei Jing, Xavier J. Reid, James L. Walshe, Paul D. Solomon, Daniel H. Tran, Daniel Ford, Jason K. K. Low, Lorna E. Wilkinson‐White, Toby Passioura, , Joel P. Mackay

The paper identifies cyclic peptides that selectively inhibit BET BD paralogues by exploiting sequence differences and conformational dynamics, achieving high selectivity over existing inhibitors.

bioRxiv · Sep 24, 2025 · PreprintBiochemistry