Author

Toby Passioura

The University of SydneyORCID 0000-0002-6089-5067Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Assay:proteomics· 1

Frequent Co-Authors

Richard J. PayneiD· 2 shared Alexander R. NormaniD· 1 shared Biswaranjan MohantyiD· 1 shared Charlotte FranckiD· 1 shared Daniel FordiD· 1 shared Daniel H. TraniD· 1 shared Hiroaki SugaiD· 1 shared Huy T. NguyeniD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersBiochemistry

Richard J. PayneORCID

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2 papers

Recent·Most cited

De novo Cyclic Peptides Allow Visualisation of the Monomeric and Functional Amyloid Conformations of the Kinase RIPK3

Jessica A. Buchanan, Olivia Lavidis, Nicholas J. Shields, Katriona Harrison, Huy T. Nguyen, Richard J. Payne, Toby Passioura, Megan C. Steain, Margaret Sunde

The paper identifies cyclic peptides that bind RIPK3's RHIM-containing region, enabling visualization of its monomeric and functional amyloid conformations in live cells.

Biochemical Journal · Jan 7, 2026Peer-reviewedBiochemistry

Peptide molecular glues select between BET paralogues by exploiting allosteric sites and conformational dynamics

Karishma Patel, Biswaranjan Mohanty, Alexander R. Norman, Charlotte Franck, Petr Pachl, Lihua Yang, Xuefei Jing, Xavier J. Reid, James L. Walshe, Paul D. Solomon, Daniel H. Tran, Daniel Ford, Jason K. K. Low, Lorna E. Wilkinson‐White, Toby Passioura, , Joel P. Mackay

The paper identifies cyclic peptides that selectively inhibit BET BD paralogues by exploiting sequence differences and conformational dynamics, achieving high selectivity over existing inhibitors.

bioRxiv · Sep 24, 2025 · PreprintBiochemistry