Author

Y. Karami

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Approach:statistical model· 2 Approach:biophysical modeling· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Organism:E. coli· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1

Frequent Co-Authors

M. Nilges· 2 shared A. Izadi· 1 shared A. Lopez Castilla· 1 shared A. Ori· 1 shared B. Bardiaux· 1 shared B. Olofsson· 1 shared D. Tang· 1 shared E. Bignon· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersImmunology

M. Nilges

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Cysteine hyperoxidation rewires communication pathways in the nucleosome and destabilizes the dyad

Y. Karami, E. Bignon

The paper uses MD simulations and network analysis to show that histone H3 C110 hyperoxidation alters nucleosome structure and destabilizes the dyad.

bioRxiv · Oct 20, 2023Biophysics

The increased hinge flexibility of an IgG1-IgG3 hybrid monoclonal enhances Fc-mediated protection against group A streptococci

A. Izadi, Y. Karami, E. Bratanis, S. Wrighton, H. Khakzad, M. Nyblom, B. Olofsson, L. Happonen, D. Tang, M. Nilges, J. Malmström, W. Bahnan, O. Shannon, L. Malmström, P. Nordenfelt

This study shows that increasing Fc flexibility in an IgG1-IgG3 hybrid monoclonal antibody enhances opsonic function and protection against group A streptococci.

bioRxiv · Oct 14, 2023 · PreprintImmunology

Computational and biochemical analysis of type IV Pilus dynamics and stability

Y. Karami, A. Lopez Castilla, A. Ori, J.-L. Thomassin, B. Bardiaux, T. E. Malliavin, N. Izadi-Pruneyre, O. Francetic, M. Nilges

The paper uses molecular dynamics simulations and biochemical experiments to study T4P stability, identifying a calcium-binding site important for function and suggesting it as a drug target.

bioRxiv · Apr 14, 2021Biochemistry