Author

M. Nilges

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Assay:structural biology· 3 Approach:biophysical modeling· 2 Organism:E. coli· 2 Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 2 Organism:bacteria (other)· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

B. Bardiaux· 3 shared N. Izadi-Pruneyre· 3 shared O. Francetic· 2 shared Y. Karami· 2 shared A. Haouz· 1 shared A. Izadi· 1 shared A. Lopez Castilla· 1 shared A. Lopez-Castilla· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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3 shared papersMicrobiology

B. Bardiaux

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

The increased hinge flexibility of an IgG1-IgG3 hybrid monoclonal enhances Fc-mediated protection against group A streptococci

A. Izadi, Y. Karami, E. Bratanis, S. Wrighton, H. Khakzad, M. Nyblom, B. Olofsson, L. Happonen, D. Tang, M. Nilges, J. Malmström, W. Bahnan, O. Shannon, L. Malmström, P. Nordenfelt

This study shows that increasing Fc flexibility in an IgG1-IgG3 hybrid monoclonal antibody enhances opsonic function and protection against group A streptococci.

bioRxiv · Oct 14, 2023 · PreprintImmunology

Structure and dynamic association of an assembly platform subcomplex of the bacterial type II secretion system

R. Dazzoni, Y. Li, A. Lopez-Castilla, S. Brier, A. Mechaly, F. Cordier, A. Haouz, M. Nilges, O. Francetic, B. Bardiaux, N. Izadi-Pruneyre

The paper determines the structure of the PulL-PulM heterodimer in the T2SS assembly platform and proposes a model for its dynamic role in pseudopilus polymerization.

bioRxiv · Jul 16, 2022Microbiology

Dynamic interplay between a TonB dependent heme transporter and a TonB protein in a membrane environment

K. Somboon, O. Melling, M. Lejeune, G. M.S. Pinheiro, A. Paquelin, B. Bardiaux, M. Nilges, P. Delepelaire, S. Khalid, N. Izadi-Pruneyre

The paper uses molecular dynamics simulations to study the interaction between a heme transporter and a TonB-like protein in E. coli, revealing dynamic interactions and validating them experimentally.

bioRxiv · Apr 21, 2021Biophysics

Computational and biochemical analysis of type IV Pilus dynamics and stability

Y. Karami, A. Lopez Castilla, A. Ori, J.-L. Thomassin, B. Bardiaux, T. E. Malliavin, N. Izadi-Pruneyre, O. Francetic, M. Nilges

The paper uses molecular dynamics simulations and biochemical experiments to study T4P stability, identifying a calcium-binding site important for function and suggesting it as a drug target.

bioRxiv · Apr 14, 2021Biochemistry