Author

L. Malmström

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Biochemistry· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Assay:proteomics· 5 Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Organism:human· 3 Organism:bacteria (other)· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Organism:mouse· 1

Frequent Co-Authors

J. Malmström· 5 shared L. Happonen· 4 shared H. Khakzad· 3 shared P. Nordenfelt· 3 shared A. Bläckberg· 2 shared A. Izadi· 2 shared D. Tang· 2 shared E. Hjortswang· 2 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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5 shared papersImmunology

J. Malmström

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Multi-Modal Mass Spectrometry Identifies a Conserved Protective Epitope in S. pyogenes Streptolysin O

D. Tang, C. A. Gueto-Tettay, E. Hjortswang, J. Ströbaek, S. Ekström, L. Happonen, L. Malmström, J. Malmström

This study uses multi-modal mass spectrometry to identify a conserved protective epitope in Streptolysin O from S. pyogenes, which could inform vaccine and therapeutic development.

bioRxiv · Dec 2, 2023 · PreprintBiochemistry

Dissecting the properties of circulating IgG against Group A Streptococcus through a combined systems antigenomics-serology workflow

S. Chowdhury, A. Gomez Toledo, E. Hjortswang, J. T. Sorrentino, N. E. Lewis, A. Bläckberg, S. Ekström, A. Izadi, P. Nordenfelt, L. Malmström, M. Rasmussen, J. Malmström

This paper develops a combined systems antigenomics-serology workflow to characterize circulating IgG against Group A Streptococcus, revealing antigen repertoire and functional properties of antibodies in healthy and infected individuals.

bioRxiv · Nov 7, 2023 · PreprintImmunology

The increased hinge flexibility of an IgG1-IgG3 hybrid monoclonal enhances Fc-mediated protection against group A streptococci

A. Izadi, Y. Karami, E. Bratanis, S. Wrighton, H. Khakzad, M. Nyblom, B. Olofsson, L. Happonen, D. Tang, M. Nilges, J. Malmström, W. Bahnan, O. Shannon, L. Malmström, P. Nordenfelt

This study shows that increasing Fc flexibility in an IgG1-IgG3 hybrid monoclonal antibody enhances opsonic function and protection against group A streptococci.

bioRxiv · Oct 14, 2023 · PreprintImmunology

Opsonization by non-neutralizing antibodies can confer protection to SARS-CoV-2 despite Spike-dependent modulation of phagocytosis

W. Bahnan, S. Wrighton, M. Sundwall, A. Bläckberg, O. Larsson, U. Höglund, H. Khakzad, M. Godzwon, M. Walle, E. Elder, L. Happonen, O. Andre, J. Kumra Ahnlide, T. Hellmark, V. Wendel-Hansen, , P. Nordenfelt

This study shows that non-neutralizing Spike-specific antibodies can enhance phagocytosis of SARS-CoV-2 by monocytes, potentially offering protection despite not neutralizing the virus.

bioRxiv · Oct 14, 2021Immunology

Streptococcus pyogenes forms serotype and local environment-dependent inter-species protein complexes

S. Chowdhury, H. Khakzad, G. E. Bergdahl, R. Lood, S. Ekstrom, D. Linke, L. Malmström, L. Happonen, j. Malmström

This study identifies serotype- and microenvironment-dependent protein interactions between Streptococcus pyogenes and host proteins using mass spectrometry and modeling.

bioRxiv · Feb 9, 2021Microbiology