Author

Y. Ortiz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Research Focus:cell signaling & trafficking· 2 Organism:human· 2 Organism:mouse· 2 Assay:proteomics· 2 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

K. Anasti· 2 shared K. Cronin· 2 shared M. Reth· 2 shared S. M. Alam· 2 shared A. K. Pane· 1 shared A. P. Kane· 1 shared A. Seoane· 1 shared A. Spill· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersImmunology

K. Anasti

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Class-specific sensing of HIV-1 antigens by the B cell antigen receptor depends on the CH1 domain

Y. Ortiz, K. Anasti, A. K. Pane, K. Cronin, S. M. Alam, M. Reth

This study shows that IgM and IgG1 BCRs differ in antigen sensing based on valency, with IgM preferring monovalent and IgG1 preferring polyvalent antigens, and identifies the CH1 domain as responsible for this difference.

bioRxiv · Dec 13, 2023 · PreprintImmunology

Fundamental parameters governing the transmission of conjugative plasmids

J. Rodriguez-Grande, Y. Ortiz, M. d. P. Garcillan-Barcia, F. de la Cruz, R. Fernandez

The paper identifies two key parameters governing plasmid transmission dynamics and shows they are characteristic of the plasmid transfer machinery.

bioRxiv · Jul 11, 2023 · PreprintMicrobiology

Orthogonal Gene Engineering Enables CD8+ T Cells to Control Tumors through a Novel PD-1+ TOX-indifferent Synthetic Effector State

J. Corria-Osorio, S. J. Carmona, E. Stefanidis, M. J. Andreatta, T. Muller, Y. Ortiz, B. Seijo, W. Castro, C. Jimenez-Luna, L. Scarpellino, C. Ronet, A. Spill, E. Lanitis, S. A. Luther, P. Romero, , G. Coukos

This study shows that orthogonal gene engineering of CD8+ T cells with IL-2 variant, PD1-decoy, and IL-33 enables tumor control through a novel PD-1+ TOX-indifferent synthetic effector state.

bioRxiv · Feb 18, 2022 · PreprintImmunology

B cells discriminate HIV-1 Envelope protein affinities by sensing antigen binding association rates

M. A. Hossain, K. Anasti, B. Watts, K. Cronin, A. P. Kane, R. J. Edwards, D. Easterhoff, J. Zhang, W. Rountree, Y. Ortiz, L. Verkoczy, M. Reth, S. M. Alam

This study investigates how B cells distinguish HIV-1 Env proteins based on binding kinetics rather than equilibrium dissociation constants.

bioRxiv · Jan 14, 2022 · PreprintImmunology

Polymorphisms in Brucella Carbonic anhydrase II mediate CO2 dependence and fitness in vivo

J. M. Garcia-Lobo, Y. Ortiz, C. Gonzalez-Riancho, A. Seoane, B. Arellano-Reynoso, F. J. Sangari

bioRxiv · Oct 15, 2019Microbiology