K. Cronin

Class-specific sensing of HIV-1 antigens by the B cell antigen receptor depends on the CH1 domain

This study shows that IgM and IgG1 BCRs differ in antigen sensing based on valency, with IgM preferring monovalent and IgG1 preferring polyvalent antigens, and identifies the CH1 domain as responsible for this difference.

Germline-targeting SOSIP trimer immunization elicits precursor CD4 binding-site targeting broadly neutralizing antibodies in infant macaques.

This study shows that a multi-dose immunization with germline-targeting SOSIP vaccines induces precursor broadly neutralizing antibodies in infant macaques, similar to adult responses.

Humanized antibody potently neutralizes all SARS-CoV-2 variants by a novel mechanism

The paper describes a humanized antibody, SP1-77, that neutralizes all SARS-CoV-2 variants by blocking membrane fusion instead of ACE2 receptor binding.

B cells discriminate HIV-1 Envelope protein affinities by sensing antigen binding association rates

This study investigates how B cells distinguish HIV-1 Env proteins based on binding kinetics rather than equilibrium dissociation constants.

Different adjuvanted pediatric HIV envelope vaccines induced distinct plasma antibody responses despite similar B cell receptor repertoires in infant rhesus macaques.

The functions of SARS-CoV-2 neutralizing and infection-enhancing antibodies in vitro and in mice and nonhuman primates

This study examines SARS-CoV-2 neutralizing and infection-enhancing antibodies, showing in vitro enhancement does not always lead to in vivo disease enhancement, but can cause increased lung inflammation in monkeys.

Microbial community dynamics of surface water in British Columbia, Canada

The paper compares methods for measuring E. coli in two watersheds, finding variability in results and suggesting alternative microbial indicators for fecal contamination.