Y. S. Choi

Multimodal mechano-microscopy reveals mechanical phenotypes of breast cancer spheroids in three dimensions

This study uses multimodal mechano-microscopy to analyze mechanical properties of breast cancer spheroids in 3D environments, revealing differences in elasticity and invasion behavior between non-metastatic and metastatic spheroids.

Tumor spheroid elasticity estimation using mechano-microscopy combined with a conditional generative adversarial network

This study trains a conditional generative adversarial network to estimate tumor spheroid elasticity from phase difference images, showing improved robustness to noise compared to traditional methods.

Polymer-mediated oligonucleotide delivery enables construction of barcoded 3D cultures for spatial single-cell analysis

The paper introduces a method to create barcoded 3D cell cultures for spatial single-cell analysis using polymer-mediated oligonucleotide delivery and multiplex single-cell RNA sequencing.

RNA binding is essential for NONO condensates to modulate pre-mRNA processing in neuroblastoma

This study identifies NONO's role in neuroblastoma by showing its RNA binding is essential for forming condensates that regulate pre-mRNA processing and oncogenic gene expression.

Matrix stiffness controls ciliogenesis and centriole position

This study shows that substrate stiffness affects cilia length and centriole position in chondrocytes, highlighting tissue-specific mechanosensing and its role in mechanosignalling.

Renoprotective effects Of Dexmedetomidine against ischemia-reperfusion injury in streptozotocin-induced diabetic rats

This study investigates the renoprotective effects of dexmedetomidine in diabetic rats with ischemia-reperfusion injury, finding that post-treatment is more effective than pre-treatment.