Alternative splice variants of the mitochondrial fission protein DNM1L/Drp1 regulate mitochondrial dynamics and cell fate in ovarian cancer.
Z. Javed, D. H. Shin, W. Pan, S. R. White, Y. S. Kim, A. T. Elhaw, S. Kamlapurkar, Y.-Y. Cheng, J. C. Benson, A. E. Abdelnaby, R. Phaeton, H.-G. Wang, S. Yang, M. L. G. Sullivan, C. St. Croix, , N. Hempel
This study identifies an alternative splice variant of Drp1 in ovarian cancer that promotes metastasis and chemoresistance by altering mitochondrial dynamics.
bioRxiv · Sep 20, 2023Cancer Biology