Plug-and-play assembly of biodegradable ionizable lipids for potent mRNA delivery and gene editing in vivo
Xuexiang Han, Ying Xu, Adele S. Ricciardi, Junchao Xu, Yan Xiang, Rohan Palanki, Vivek Chowdhary, Lulu Xue, Ningqiang Gong, Mohamad‐Gabriel Alameh, William H. Peranteau, James M. Wilson, Daniel Reker, Drew Weissman, Michael J. Mitchell
This study develops a combinatorial chemistry approach to create biodegradable ionizable lipids for efficient mRNA delivery and gene editing in vivo.
Proceedings of the National Academy of Sciences · May 26, 2026Peer-reviewedBioengineering