Global loss of responsiveness in key regulator metabolites and elevated enzyme proteins as metabolic dysregulation in skeletal muscle and liver of obese mice during starvation
D.F. Li, Keigo Morita, Toshiya Kokaji, Atsushi Hatano, Akiyoshi Hirayama, Tomoyoshi Soga, Yutaka Suzuki, Masaki Matsumoto, Takaho Tsuchiya, Haruka Ozaki, Satoshi Ohno, Hiroshi Inoue, Yuka Inaba, Hikaru Sugimoto, Yifei Pan, Shinya Kuroda
The paper examines metabolic adaptations during starvation in obese mice, finding impaired responsiveness and elevated enzyme expression in skeletal muscle and liver.
bioRxiv · Jan 22, 2025 · PreprintSystems Biology