Generation of hypoimmunogenic gastric insulin-secreting organoids
Anna Ada Dattoli, Matthew E. Brown, Bradley Pearson, Zachary Feinstein, Ying Lan, Vasumati Polavarapu, Max Zhou, Ryan Nachman, Yosip Kelemen, Shahin Rafii, Rémi J. Creusot, Todd M. Brusko, Qiao Zhou, Xiaofeng Huang
This study generates hypoimmunogenic gastric insulin-secreting organoids (GINS) and shows PD-L1 engineering improves their survival under immune challenge.
bioRxiv · Jul 13, 2026 · PreprintImmunology