This study generates hypoimmunogenic gastric insulin-secreting organoids (GINS) and shows PD-L1 engineering improves their survival under immune challenge.

bioRxiv · Jul 13, 2026 · PreprintImmunology

A universal platform for simultaneous TCRα/β removal enables safer and more potent TCR therapies and autoimmune modeling

Giorgia Zanetti, Mateusz Legut, Austin Chen, Farshid Fathi, Nathan Suek, Nato Teteloshvili, Hao Wei Li, Xiaolan Ding, Daniel Traum, Klaus H. Kaestner, Ryan E. Hoang, Edwin Bremer, Andrew Kelvin Sewell, Audrey V. Parent, Rémi J. Creusot, , Mohsen Khosravi Maharlooei

This paper presents a CRISPR-based platform that removes endogenous TCRα/β chains to enhance transgenic TCR function and safety in T-cell therapies and autoimmune modeling.

bioRxiv · Feb 20, 2026 · PreprintImmunology

The nascent transcriptome delineates the regulatory landscape in human health and disease

Sagar R Shah, You Chen, Alden King-Yung Leung, Priscila V. Castilho Navarro, Mauricio I. Paramo, Juhi Gupta, Aishwarya Gurumurthy, Rebuma Firdessa-Fite, Annika K K Weimer, Kelly Cochran, Austin Wang, Qian Du, Ahmed Mohyeldin, Dieter M. Egli, Anshul Bharat Kundaje, , Haiyuan Yu

The paper presents a high-resolution atlas of transcriptional regulatory elements in human tissues and disease states using PRO-cap and deep learning models to prioritize noncoding variants.

bioRxiv · Sep 24, 2025 · PreprintGenomics