Data-driven discovery of cell-type-directed network-correcting combination therapy for Alzheimer's disease
Yaqiao Li, Carlota Pereda Serras, Jessica R. Blumenfeld, Min Xie, Yanxia Hao, Elise Deng, You Young Chun, Julia Holtzman, Alice An, Seo Yeon Yoon, Xinyu Tang, Antara T. Rao, Sarah R. Woldemariam, Alice Tang, Alex Zhang, , Marina Sirota
The paper identifies a cell-type-directed combination therapy for Alzheimer's disease using single-cell transcriptomics and drug databases, showing improved memory and reduced pathologies in a mouse model.
bioRxiv · Dec 9, 2024 · PreprintSystems Biology