Shigeomi Shimizu

Partitioning of nuclear material into apoptotic fragments through establishment of asymmetric cell death morphology

This study identifies a new apoptotic morphology, AsyCDM, where apoptotic cells asymmetrically partition nuclear material into apoptotic bodies via ROCK1-dependent actomyosin contraction.

Biogenesis and antigen presentation properties of dendritic cell-derived apoptotic bodies

This study shows that apoptotic dendritic cells release large extracellular vesicles called apoptotic bodies that can directly present antigens and modulate immune responses.

ULK1-regulated AMP sensing by AMPK and its application for the treatment of chronic kidney disease

This study identifies ULK1-dependent AMPK activation mechanisms and shows MK8722 improves renal function in CKD.

Branched-chain amino acid metabolism is a crucial modulator of cellular senescence

This study shows that changes in branched-chain amino acid (BCAA) metabolism, specifically reduced BCAT2 activity, drive cellular senescence in cultured cells and mice, and link aging to altered BCAA metabolism in humans.