Author

Yuyan Gong

SeekGene BioSciences Co. Ltd., Beijing, China;

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 2 Genomics· 2 Genetics· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Organism:human· 4 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Assay:scRNA-seq· 3 Research Focus:clustering· 2 Assay:DNA methylation· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

Guangxin ZhangiD· 2 shared Guoqin Sang· 2 shared Bing YaoiD· 1 shared Binliang LiuiD· 1 shared Changyuan GuoiD· 1 shared Chuyuan Lou· 1 shared Dan Xu· 1 shared Deyu MengiD· 1 shared

Activity by Year

2023-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersGenomics

Guangxin ZhangORCID

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Cellular context shapes the transcriptomic impact of somatic variants

Peisen Sun, Peng Jia, Chuyuan Lou, Xiaona Li, Miaojing Li, Ruifen Zhang, Hui Lin, Xiujuan Li, Yunsong Zhou, Shuzheng Cai, Zexin Zhang, Pengyu Zhang, Tun Xu, Songbo Wang, Yudong Wang, , Kai Ye

The paper shows that somatic variants' transcriptomic impact depends on cellular context, not just sequence, using single-cell transcriptomics and new tools.

bioRxiv · Nov 2, 2026 · PreprintGenetics

Scalable methylome-transcriptome profiling resolves clonal organization in human hematopoiesis

Jikai Shao, Mengyang Chen, Yan Liu, Jinnan Sun, Guangxin Zhang, Yan Zheng-yi, Hongying Lin, Miaomiao Ren, Shanshan Pei, Jun Peng, Yuyan Gong, Shouwen Wang

This paper introduces Droplet-MT, a method for joint methylome and transcriptome profiling, enabling clonal organization analysis in human hematopoiesis with high scalability and resolution.

bioRxiv · Oct 11, 2026 · PreprintGenomics

ctDNA Release Heterogeneity in Luminal Breast Cancer Revealed by Single-Cell Multi-Omics Spatial Analysis

Hengyi Xu, Pengming Pu, Binliang Liu, Yuyan Gong, Jiang Wu, Changyuan Guo, Heng Cao, Ziqi Jia, Yuchen Liu, Yansong Huang, Dongxu Ma, Jiayi Li, Zizhao Guo, Tongxuan Shang, Lin Cong, , Jiaqi Liu

The paper identifies cellular and spatial determinants of ctDNA release in HR+/HER2- breast cancer using single-cell multi-omics spatial analysis, linking tumor states, mutations, and immune interactions to ctDNA release patterns.

bioRxiv · Sep 28, 2026 · PreprintCancer Biology

A Self-Assembling Immune-Featured Osteosarcoma Patient/PDX Derived Organoid Model and Biobank for Personalized Immune Therapy

Haoran Mu, Yining Tao, Jinzeng Wang, Xin He, Qi Zhang, Weixi Chen, Bing Yao, Sen Ding, Xiyu Yang, Liyuan Zhang, Hongsheng Wang, Dongqing Zuo, Jiakang Shen, Mengxiong Sun, Haoyu Wang, , Yingqi Hua

The paper develops a patient/PDX-derived osteosarcoma organoid model and biobank to enable rapid testing of personalized immune therapies and drug development.

bioRxiv · Aug 11, 2024 · PreprintCancer Biology

High throughput detection of variation in single-cell whole transcriptome through streamlined scFAST-seq

Guoqin Sang, Jiaxin Chen, Meng Zhao, Huanhuan Shi, Jinhuan Han, Jiacheng Sun, Ying Guan, Xingyong Ma, Guangxin Zhang, Yuyan Gong, Yi Chen Zhao, Shaozhuo Jiao

This paper introduces scFAST-seq, a high-throughput single-cell full-length RNA sequencing method that improves detection of non-polyadenylated transcripts and RNA velocity, and enables simultaneous mutation and cellular status identification in tumor cells.

bioRxiv · Mar 19, 2023 · PreprintGenomics