Thibaut Molinié

Stress adaptation of mitochondrial protein import by OMA1-mediated degradation of DNAJC15

The paper shows OMA1 regulates mitochondrial protein import and OXPHOS biogenesis under stress by degrading DNAJC15, affecting protein translocation and organelle communication.

Non-coding exon splicing orchestrates tissue-specific expression of two functionally distinct mitochondrial isoforms of Mitofusin 2

The paper identifies a tissue-specific mitochondrial isoform of MFN2 generated by non-coding exon splicing and shows its distinct functional role in lipid trafficking.

Preserved respiratory chain capacity and physiology in mice with profoundly reduced levels of mitochondrial respirasomes

This study shows that mice with reduced respirasomes maintain normal bioenergetics and physiology, suggesting respirasomes are not essential for basic function but may have other roles.

MitoMouse is a model reconstruction of murine mitochondrial metabolism

The paper develops a mouse-specific mitochondrial metabolic model called mitoMouse, validated to accurately model CoQ reduction in response to increased malate import.