Z. Cheng

This paper presents a genetic circuit that alleviates lactose intolerance by boosting beta-galactosidase activity and restoring gut microbiota through pH regulation in mice.

The paper identifies two HOMEOBOX gene alterations responsible for leaf form diversity in heirloom tomatoes.

This study develops a cell-based chimeric vaccine against SARS-CoV-2 that induces strong T cell immunity and neutralizing antibodies without toxicity.

This study demonstrates that ADXS-NEO, a personalized Listeria monocytogenes vaccine, effectively targets tumor-specific mutations and controls tumor growth in mice by inducing neoantigen-specific T cell responses.

The paper determines the crystal structure of the INTS3/INTS6 complex and shows that INTS3 dimerization is crucial for DSB repair.

This paper applies federated learning to drug discovery, showing it improves prediction accuracy over centralized training with biased and small datasets.

This paper introduces a NIR-II cell tracker for real-time monitoring of stem cell behavior in vivo, revealing differential responses to diseased environments and enabling long-term tracking beyond 30 days.

This study identifies accessory genome elements in Pseudomonas aeruginosa that influence virulence towards C. elegans, including a viral-like mobile element restricted by CRISPR-Cas systems.

The paper investigates how leaf shape affects fruit quality and yield in tomato cultivars, finding that rounder leaves correlate with higher sugar content and yield.

This study identifies βVPE as a key enzyme in Arabidopsis thaliana that activates proproteases for tapetal degradation and pollen development.

This study characterizes the metallo-β-lactamase SPS-1 from Sediminispirochaeta smaragdinae, revealing a novel metal binding site that challenges inhibitor design.

This study identifies 916 differentially expressed genes in rat cells over-expressing U1 snRNA, with 12 enriched pathways linked to cancer.