PathologybioRxiv
MEKK3-TGFβ crosstalk regulates inward arterial remodeling
H. Deng, Y. Xu, X. Hu…·M. Simons
This study identifies endothelial MEKK3 as a regulator of inward arterial remodeling through TGFβ-Smad2/3 signaling, leading to hypertension and atherosclerosis.
DOI 10.1073/pnas.2112625118