J. D. Humphrey

A fast, robust method for quantitative assessment of collagen fibril architecture from transmission electron micrographs

The paper introduces a semi-automated method to quantify collagen fibril architecture from TEM images, validated on mouse aortic samples.

Ex Vivo Biomechanical Characterization of Umbilical Vessels: Possible Shunts in Congenital Heart Palliation

This study biomechanically compares umbilical veins and arteries with subclavian and pulmonary arteries to evaluate their suitability as shunts for congenital heart palliation.

Fibronectin-integrin α5 signaling promotes thoracic aortic aneurysm in a mouse model of Marfan syndrome

This study shows that fibronectin-integrin α5 signaling drives thoracic aortic aneurysms in Marfan syndrome mice, with a 5/2 chimera mutation reducing aneurysm severity.

Compensatory aortic remodeling in Marfan syndrome protects against sexually dimorphic rupture during a BAPN challenge

The paper examines sexual dimorphism in aortic remodeling and rupture resistance in Marfan syndrome mice with and without BAPN exposure, finding compensatory mechanisms in females and males that protect against rupture.

Lonafarnib improves cardiovascular function and survival in a mouse model of Hutchinson-Gilford Progeria Syndrome

Lonafarnib improves cardiovascular function and survival in a progeria mouse model by reducing pulse wave velocity and enhancing left ventricular diastolic function.

Critical Pressure of Intramural Delamination in Aortic Dissection

The paper uses computational models to show how pressure and mechanical factors influence the initiation and propagation of aortic tears leading to dissection.

Uncertainty quantification in subject-specific estimation of local vessel mechanical properties

The paper introduces an uncertainty quantification method for estimating local vessel mechanical properties using Bayesian techniques and applies it to mouse aorta data.

Genetic Background Dictates Aortic Fibrosis in Hypertensive Mice

This study shows that genetic background strain influences aortic fibrosis in hypertensive mice, with C57BL/6J mice showing more maladaptive remodeling than 129SvEv mice.

Fast, Rate-Independent, Finite Element Implementation of a 3D Constrained Mixture Model of Soft Tissue Growth and Remodeling

This paper introduces a fast finite element implementation of a 3D constrained mixture model for simulating soft tissue growth and remodeling, showing quadratic convergence and applications to aortic aneurysm enlargement.

Paradoxical Aortic Stiffening and Subsequent Cardiac Dysfunction in Hutchinson-Gilford Progeria Syndrome

This study shows that aortic stiffening and cardiac dysfunction in HGPS mice occur due to loss of smooth muscle function and proteoglycan accumulation, independent of sex, with potential therapeutic implications.